Harvard University · edX
Fundamentals of TinyML
4.567 ratingsFocusing on the basics of machine learning and embedded systems, such as smartphones, this course will introduce you to the “language” of TinyML.
Overview
Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.
The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment.
Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies.
This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.
Syllabus 7
- Introduction & Shortcomings of Current Approaches 2.5 hours
This module introduces you to the course, outlines the shortcomings of current toxicity testing approaches, and shows how EBT can help to overcome these shortcomings.
- History and Causation 3.5 hours
This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradfo…
- Systematic Review and Meta-Analysis 3 hours
This module shows how to perform systematic reviews and meta-analyses. You will learn the history of both methods and will receive step-by-step instructions on how to perform systematic reviews and meta-analyses using examples from the research activities of the instructors.
- Risk of Bias & Application to Test Methods Comparison 2 hours
This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by t…
- Quality Assurance, Good Practices, and Validation 3.5 hours
Quality control is a very important aspect of not only modern toxicology but the entirety of life sciences. The first lesson in this module demonstrates the importance of performing quality control on your experiments. The second lesson is connected with the first one because validation of an alter…
- Biometrical Tools & Future Perspectives 3 hours
Evidence-based toxicology requires some knowledge of bioinformatics. The first lesson in the module teaches you some biostatistical tools you can apply when analyzing predectivity, specificity, and sensitivity of a method. You will also learn how to identify biases in a study with the help of bioin…
- Summative Assessment - Systematic Review Assignment 2.5 hours
The final week of the course is devoted to completing the Systematic Review Assignment. You will use SysRev to review at least 20 abstracts, apply inclusion and exclusion criteria, render decisions, and resolve conflicts with other reviewers.
Skills you'll practise
Advantages and disadvantages
Advantages
- Structured courses with graded quizzes, assignments and deadlines you can reset.
- A shareable certificate from the university or company when you pay.
- Financial aid is often approved for students in India (apply 15 days before you need it).
- Taught by Johns Hopkins University, one of the strongest names in its field.
- Rated 4.7 out of 5 by 123 learners.
- Self-paced: start any time.
- A clear syllabus (7 parts) you can see before you start.
Disadvantages
- Paid after a 7-day free trial (Coursera Plus or per course).
- Some courses can be audited for free, but graded work and certificates need payment.
Some points apply to every course of this kind; see how we rank.
This course is paid. Here is how to take it for free
- Free trials: You can start a 7-day free trial for many individual courses, Specializations, or a Coursera Plus subscription to test full course features. Cancel before the seventh day if you do not want to be charged.
- Financial aid: If you cannot afford the fee for a certificate, you can apply for financial aid through the link on the course home page by filling out an application about your background and goals.
Taught by
- Thomas HartungProfessor, Environmental Health and Engineering
- Lena SmirnovaResearch Associate, Center for Alternatives to Animal Testing
Johns Hopkins University is in Tier 1: world-leading universities and India's top institutes of our institution ranking (93/100).
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